Inhibition of CD1 expression in human dendritic cells during intracellular infection with Leishmania donovani.

نویسندگان

  • Joseph L Amprey
  • Gerald F Späth
  • Steven A Porcelli
چکیده

Dendritic cells can initiate antimicrobial responses by CD1-mediated presentation of pathogen-derived glycolipids. We show that the protozoan Leishmania donovani inhibits CD1 expression and prevents activation of CD1-restricted T cells by dendritic cells. Evasion of presentation by CD1 may represent a Leishmania survival strategy to avoid recognition of abundant parasite glycolipids.

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عنوان ژورنال:
  • Infection and immunity

دوره 72 1  شماره 

صفحات  -

تاریخ انتشار 2004